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ALDACTONE has been shown to be a tumorigen in chronic toxicity studies in rats . ALDACTONE should be used only in those conditions described under Indications and Usage. Unnecessary use of this drug should be avoided. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. ALDACTONE is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. ALDACTONE causes increased amounts of sodium and water to be excreted, while potassium is retained. ALDACTONE acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents that act more proximally in the renal tubule. Increased levels of the mineralocorticoid, aldosterone, are present in primary and secondary hyperaldosteronism. Edematous states in which secondary aldosteronism is usually involved include congestive heart failure, hepatic cirrhosis, and nephrotic syndrome. By competing with aldosterone for receptor sites, ALDACTONE provides effective therapy for the edema and ascites in those conditions. ALDACTONE counteracts secondary aldosteronism induced by the volume depletion and associated sodium loss caused by active diuretic therapy. ALDACTONE is effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, ALDACTONE inhibits the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. ALDACTONE has not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. ALDACTONE is rapidly and extensively metabolized. Sulfur-containing products are the predominant metabolites and are thought to be primarily responsible, together with ALDACTONE, for the therapeutic effects of the drug. The following pharmacokinetic data were obtained from 12 healthy volunteers following the administration of 100 mg of spironolactone daily for 15 days. On the 15th day, spironolactone was given immediately after a low-fat breakfast and blood was drawn thereafter. The pharmacological activity of spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to spironolactone were 1.10, 1.28, and 0.32, respectively. Relative to spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on spironolactone absorption was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized spironolactone by almost 100%. The clinical importance of this finding is not known. Concomitant medications included a loop diuretic in 100% of patients and an ACE inhibitor in 97%. Other medications used at any time during the study included digoxin . The primary endpoint for RALES was time to all-cause mortality. RALES was terminated early, after a mean follow-up of 24 months, because of significant mortality benefit detected on a planned interim analysis. The survival curves by treatment group are shown in Figure 1. Figure 2: The size of each box is proportional to the sample size as well as the event rate. LVEF denotes left ventricular ejection fraction, Ser Creatinine denotes serum creatinine, Cr Clearance denotes creatinine clearance, and ACEI denotes angiotensin-converting enzyme inhibitor. Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial. Short-term preoperative treatment of patients with primary hyperaldosteronism. Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are judged to be poor operative risks or who decline surgery. Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia . For the management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. ALDACTONE is also indicated for patients with congestive heart failure taking digitalis when other therapies are considered inappropriate. Aldosterone levels may be exceptionally high in this condition. ALDACTONE is indicated for maintenance therapy together with bed rest and the restriction of fluid and sodium. For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response. ALDACTONE is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure . Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension , and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. Some antihypertensive drugs have smaller blood pressure effects . These considerations may guide selection of therapy. Usually in combination with other drugs, ALDACTONE is indicated for patients who cannot be treated adequately with other agents or for whom other agents are considered inappropriate. For the treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate. ALDACTONE is also indicated for the prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate. To increase survival, and to reduce the need for hospitalization for heart failure when used in addition to standard therapy. The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developing toxemia. Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. ALDACTONE is indicated in pregnancy when edema is due to pathologic causes just as it is in the absence of pregnancy , but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort that is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate. ALDACTONE is contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hyperkalemia, Addison's disease, and with concomitant use of eplerenone. Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with ALDACTONE therapy. Excessive potassium intake may cause hyperkalemia in patients receiving ALDACTONE . ALDACTONE should not be administered concurrently with other potassium-sparing diuretics. ALDACTONE, when used with ACE inhibitors or indomethacin, even in the presence of a diuretic, has been associated with severe hyperkalemia. Extreme caution should be exercised when ALDACTONE is given concomitantly with these drugs. ALDACTONE should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma. Lithium generally should not be given with diuretics . All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance, e.g., hypomagnesemia, hyponatremia, hypochloremic alkalosis, and hyperkalemia. Serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance, irrespective of cause, include dryness of the mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hyperkalemia may occur in patients with impaired renal function or excessive potassium intake and can cause cardiac irregularities, which may be fatal. Consequently, no potassium supplement should ordinarily be given with ALDACTONE. If hyperkalemia is suspected should be obtained. However, it is important to monitor serum potassium levels because mild hyperkalemia may not be associated with ECG changes. Reversible hyperchloremic metabolic acidosis, usually in association with hyperkalemia, has been reported to occur in some patients with decompensated hepatic cirrhosis, even in the presence of normal renal function. ALDACTONE therapy may cause a transient elevation of BUN, especially in patients with pre-existing renal impairment. ALDACTONE may cause mild acidosis. Somnolence and dizziness have been reported to occur in some patients. Caution is advised when driving or operating machinery until the response to initial treatment has been determined. Patients who receive ALDACTONE should be advised to avoid potassium supplements and foods containing high levels of potassium, including salt substitutes. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments. Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia. Concomitant administration may lead to severe hyperkalemia. Potentiation of orthostatic hypotension may occur. Intensified electrolyte depletion, particularly hypokalemia, may occur. ALDACTONE reduces the vascular responsiveness to norepinephrine. Therefore, caution should be exercised in the management of patients subjected to regional or general anesthesia while they are being treated with ALDACTONE. Possible increased responsiveness to the muscle relaxant may result. Lithium generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effect of loop, potassium-sparing, and thiazide diuretics. Combination of NSAIDs, e.g., indomethacin, with potassium-sparing diuretics has been associated with severe hyperkalemia. Therefore, when ALDACTONE and NSAIDs are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. ALDACTONE has been shown to increase the half-life of digoxin. This may result in increased serum digoxin levels and subsequent digitalis toxicity. It may be necessary to reduce the maintenance and digitalization doses when ALDACTONE is administered, and the patient should be carefully monitored to avoid over- or under-digitalization. Hyperkalemic metabolic acidosis has been reported in patients given ALDACTONE concurrently with cholestyramine. Several reports of possible interference with digoxin radioimmunoassay by ALDACTONE, or its metabolites, have appeared in the literature. Neither the extent nor the potential clinical significance of its interference has been fully established. A dose-related for a period of one year. In two-year studies in the rat, oral administration of potassium canrenoate was associated with myelocytic leukemia and hepatic, thyroid, testicular, and mammary tumors. Neither ALDACTONE nor potassium canrenoate produced mutagenic effects in tests using bacteria or yeast. In the absence of metabolic activation, neither ALDACTONE nor potassium canrenoate has been shown to be mutagenic in mammalian tests in vitro. In the presence of metabolic activation, ALDACTONE has been reported to be negative in some mammalian mutagenicity tests in vitro and inconclusive for mutagenicity in other mammalian tests in vitro. In the presence of metabolic activation, potassium canrenoate has been reported to test positive for mutagenicity in some mammalian tests in vitro, inconclusive in others, and negative in still others. Canrenone, a major metabolite of ALDACTONE, appears in human breast milk. Because ALDACTONE has been found to be tumorigenic in rats, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother. If use of the drug is deemed essential, an alternative method of infant feeding should be instituted. Safety and effectiveness in pediatric patients have not been established. The following adverse reactions have been reported and, within each category , are listed in order of decreasing severity. Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting. Reproductive: Gynecomastia , inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding, breast pain. Carcinoma of the breast has been reported in patients taking ALDACTONE but a cause and effect relationship has not been established. Hematologic: Leukopenia , thrombocytopenia. Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis. Metabolism: Hyperkalemia, electrolyte disturbances . Musculoskeletal: Leg cramps. Renal: Renal dysfunction . Skin: Stevens-Johnson Syndrome , alopecia, pruritis. Acute overdosage of ALDACTONE may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Rarely, instances of hyponatremia, hyperkalemia, or hepatic coma may occur in patients with severe liver disease, but these are unlikely due to acute overdosage. Hyperkalemia may occur, especially in patients with impaired renal function. Induce vomiting or evacuate the stomach by lavage. There is no specific antidote. Treatment is supportive to maintain hydration, electrolyte balance, and vital functions. ALDACTONE may be employed as an initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets. ALDACTONE is administered at a daily dosage of 400 mg for three to four weeks. Correction of hypokalemia and of hypertension provides presumptive evidence for the diagnosis of primary hyperaldosteronism. ALDACTONE is administered at a daily dosage of 400 mg for four days. If serum potassium increases during ALDACTONE administration but drops when ALDACTONE is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered. After the diagnosis of hyperaldosteronism has been established by more definitive testing procedures, ALDACTONE may be administered in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, ALDACTONE may be employed for long-term maintenance therapy at the lowest effective dosage determined for the individual patient. For adults, an initial daily dosage of 50 to 100 mg of ALDACTONE administered in either single or divided doses is recommended. ALDACTONE may also be given with diuretics that act more proximally in the renal tubule or with other antihypertensive agents. Treatment with ALDACTONE should be continued for at least two weeks since the maximum response may not occur before this time. Subsequently, dosage should be adjusted according to the response of the patient. ALDACTONE in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia, when oral potassium supplements or other potassium-sparing regimens are considered inappropriate..
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twenty-one hours within six days and improve each day, and. Why are the prices of some generic drugs so darn high? That's a question many consumers have been asking lately. And now, a pair of prominent congressmen are demanding an answer from the drug industry. The letters were sent by Rep. Elijah E. Cummings of Maryland, the ranking Democrat on the House Oversight and Government Reform Committee, and Vermont independent Sen. Bernie Sanders, chairman of the Senate Subcommittee on Primary Health and Aging. They cited the example of the asthma drug albuterol sulfate. The average cost for a bottle of 100 pills was last October, the pair said. The average charge by this April was up to 4. The antibiotic doxycycline hyclate cost last October for a bottle of 500 tablets, the congressmen observed. By April, the price was id="post-9" class="post-9 page type-page status-publish has-post-thumbnail hentry">
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,849. This segment aired on the KTLA 5 Morning News on December 8, 2015. This segment aired on the KTLA 5 Morning News on December 8, 2015. This segment aired on the KTLA 5 Morning News on November 17, 2015. This segment aired on the KTLA 5 Morning News on November 17, 2015. This segment aired on the KTLA 5 Morning News on November 3, 2015. This segment aired on the KTLA 5 Morning News on November 3, 2015. This segment aired on the KTLA 5 Morning News on October 27, 2015. This segment aired on the KTLA 5 Morning News on October 27, 2015. The letters to the drug companies seek information about operational and production costs. They don't suggest any impropriety on the companies' part. But the mere fact that a congressional investigation has been launched indicates concern that generic drugs may not be priced fairly. The congressmen's action comes amid reports of major drug companies paying makers of generic versions to delay bringing their products to market and of ongoing consolidation among generic drug makers. Experts say generics are growing more expensive because of reduced competition among manufacturers and shortages of raw materials. However, that might not explain triple-digit price hikes for some drugs. He cited simvastatin, the generic equivalent of cholesterol drug Zocor, and clomipramine hydrochloride, the generic version of antidepressant Anafranil. Prices for each rose more than 650% from June 2013 to this June, Birch said. He said consumers often are unaware of such huge price hikes because they face only a copay when they buy meds at a drugstore. The skyrocketing costs are borne primarily by insurance companies, which subsequently raise people's premiums to accommodate the greater expenses, Birch said. More than 80% of U.S. prescriptions are filled with generic drugs, according to the Food and Drug Administration. The Generic Pharmaceutical Assn. says this saves consumers more than 0 billion in healthcare costs every year. But Sanders said he and Cummings decided to press for some answers from the drug industry because, even with widespread use of generics, Americans pay the highest prices in the world for prescription drugs. "The question is why," Joyce said. Each of the experts I spoke with cited industry consolidation as a key reason for rising prices. Rather than the half-dozen or so competitors that many economists believe are necessary to lead to lower prices, only two or three manufacturers now make some generic meds. Some of the biggest generic drug companies — Mylan, Actavis and Teva Pharmaceutical Industries — have been aggressively snapping up other manufacturers in recent years, reducing the number of players in the market. In July, Mylan said it would buy a controlling stake in Abbott Laboratories' generics business outside the U.S. in a deal valued at more than billion. The deal would give Mylan even more influence over prices — not to mention the lower taxes it would pay after moving its headquarters to the Netherlands. Shortages of raw materials frequently are cited as a reason for higher drug prices. Joyce said the difficulty of knowing what's actually happening throughout a drug's supply chain, which often begins in China or India, makes it hard to know whether a shortage is the result of deliberate moves. William Comanor, head of pharmaceutical economics and policy studies at UCLA, takes a different view. He said the reality is that many generic drugs may be priced too low. "The prices we pay don't account for all the costs that come with running a drug company, such as having a steady supply," he said. By Comanor's thinking, generic drug prices that are too low prevent manufacturers from investing in long-term stocks of raw materials, causing inventories abroad to rise and fall and prices in the United States to follow suit. But he said generic drug prices do sometimes show what economists call "disequilibrium," which occurs when normal supply-and-demand market forces aren't working as they should. Prices might soar for no readily apparent reason. He said critics such as Cummings and Sanders are focusing on only a handful of drugs and ignoring thousands of other "safe, affordable" generic meds. Perhaps. And if that's the case, generic drug makers have nothing to fear from a little congressional scrutiny. If, on the other hand, it can be shown that prices in some instances have skyrocketed because of unethical or unfair business practices, then the industry should feel a firmer pull on the regulatory leash. It's a fact: Prices of some generic drugs are too darn high. The industry needs to come clean on what's going on. Why are the prices of some generic drugs so darn high? That\'s a question many consumers have been asking lately. And now, a pair of prominent congressmen are demanding an answer from the drug industry.. Looking to lead a stronger, healthier life? Sign up for our Wellness Wire newsletter for all sorts of nutrition, fitness, and wellness wisdom. Please enter a valid email. Now we’re in this together. Thanks for subscribing and having us along on your health and wellness journey. Aldactone is an oral drug that’s used to reduce swelling from congestive heart failure, liver disease, nephrotic syndrome , heart failure, low potassium levels caused by other blood pressure medications, and excessive aldosterone secretion. Aldactone is a brand-name drug. It’s also available as the generic drug called spironolactone. Your dose will depend on the condition being treated and any side effects that you have. Doses range from 25 mg taken by mouth once every other day to 200 mg taken as one dose or split into 2 doses. Your doctor will decide a dose that’s right for you. You may not be able to take this drug if you have certain conditions. These include not making any urine , high potassium levels, and Addison’s disease. You also shouldn’t take this drug if you’re pregnant or breast-feeding or take the medicine eplerenone. Serious side effects include very high potassium levels, breast enlargement, and serious skin reactions. This drug has been shown to cause tumors in rats. It’s important to only take this medicine if your doctor prescribes it to you. This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration . A black box warning alerts doctors and patients to effects that may be dangerous. Appropriate use warning: This drug has been shown to cause tumors in rats during long-term exposure. It’s important to only take this medicine if your doctor prescribes it to you. While taking this drug, you should watch your potassium intake. You shouldn’t take potassium supplements, eat a diet rich in potassium, or consume salt substitutes containing potassium. Having too much potassium in your body can lead to severe problems. This can even be fatal. Talk to your doctor or a nutritionist if you are concerned about your potassium intake. This drug may cause you to have enlarged breasts . This can happen in both men and women. If this happens, your doctor may stop treatment with this drug. This symptom usually goes away once you stop taking this drug. This drug is a prescription drug. It’s available as an oral tablet. This drug is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in all strengths or forms as the brand. Talk to your healthcare provider to see if the generic will work for you. This drug may be taken as part of a combination therapy with other water pills that work on a different part of the kidney. This drug is an oral drug that’s used to reduce swelling from congestive heart failure, liver disease, nephrotic syndrome , ascites, and pulmonary edema. It’s also used to treat high blood pressure, heart failure, low potassium levels caused by other blood pressure medications, and excessive aldosterone secretion. This drug belongs to a class of drugs called aldosterone antagonists , or potassium-sparing diuretics. A class of drugs is a group of medications that work in a similar way. They are often used to treat similar conditions. This drug belongs to a class of drugs called aldosterone antagonists , or potassium-sparing diuretics. A class of drugs is a group of medications that work in a similar way. They are often used to treat similar conditions. This drug works by blocking aldosterone activity. Aldosterone is a chemical made by the body that can cause water retention. This makes certain heart, kidney, and liver conditions worse. By blocking aldosterone, your body won’t retain fluid. This process also stops potassium from being excreted by your body. This drug may lower your blood pressure by blocking aldosterone’s effect on your blood vessels. If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have any of these serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. This drug may cause drowsiness. You shouldn’t drive, use machinery, or do similar tasks that require alertness until you know how this drug affects you. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history. Aldactone can interact with other medications, herbs, or vitamins you might be taking. An interaction is when a substance changes the way a drug works. This can be harmful or cause the drugs that you take to not work as well. To help prevent interactions, your doctor should manage all of your medications carefully. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist. The use of drinks that contain alcohol can increase your risk of a sedative effect. You may have slowed reflexes, poor judgment, and sleepiness. This can be dangerous. If you drink alcohol, talk to your doctor. These drugs can increase the amount of potassium in your body to unsafe levels if taken with Aldactone. These drugs can increase the amount of potassium in your body to unsafe levels when taken with Aldactone. Taking these drugs together may also lower your blood pressure too much. These drugs can increase the amount of potassium in your body to unsafe levels if taken with Aldactone. These drugs can lower your blood pressure too much if taken with Aldactone. These drugs can decrease the amount of potassium in your body to unsafe levels if taken with Aldactone. Aldactone can increase the effects of lithium. Your doctor may lower your dose of lithium if you take these drugs together. Aldactone can increase the effect of heart drugs. Your doctor may need to adjust your dose of your heart drug. Aldactone can decrease the effects of some anesthesia drugs. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. You shouldn’t take this drug if you have anuria or don’t produce urine. You should not take this drug if you have kidney disease or kidney damage. This drug can increase your risk for electrolyte changes, such as too much nitrogen in your bloodstream. You shouldn’t take this drug if you have Addison’s disease. It can make your illnesses worse. Don’t take potassium supplements, eat a diet high in potassium, or take drugs that increase potassium levels if you have heart failure and you’re taking this drug. Dangerously high potassium levels are more likely if you have heart failure. This can be fatal. Taking this drug during pregnancy may pose a risk to the developing fetus. Tell your doctor if you’re pregnant or plan to become pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk. This drug and its metabolite pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule. This medicine shouldn’t be used in children younger than 18 years. Call your doctor if you have trouble breathing or swelling in your legs. This means that your heart disease is getting worse. Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal. The starting dose is 50–100 mg taken by mouth each day. It’s given as a single dose or split into two doses. This medication isn’t approved for use in children younger than 18 years. There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule. The dose ranges from 25–100 mg per day. This medication isn’t approved for use in children younger than 18 years. There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule. The starting dose is 100 mg taken by mouth each day. It’s given as a single dose or split into two doses. Some people may start as low as 25 mg per day or as high as 200 mg per day. This medication isn’t approved for use in children younger than 18 years. There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule. The starting dose is 12.5–25 mg taken by mouth once per day. Your doctor may increase or decrease your dose based on how you respond to the drug. Some people may take 50 mg once per day and others may take 25 mg once every other day. This medication isn’t approved for use in children younger than 18 years. Seniors should take 12.5–25 mg once per day for heart failure. You shouldn’t take more than 25 mg per day. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. This medication isn’t approved for use in children younger than 18 years. There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. This drug comes with serious risks if you don't take it as prescribed. If you do not take this drug, your blood pressure will stay high. This can lead to a heart attack or stroke. Your body may also become overloaded with fluid. This can cause serious worsening of kidney and liver disease. If you stop taking this drug, you may start retaining water. You may also have a sudden increase in your blood pressure. This can lead to a heart attack or stroke. If you don’t take this drug on schedule, your blood pressure might not be controlled. This can lead to a heart attack or stroke. If you forget to take your dose, take it as soon as you remember. If it’s just a few hours before the time for your next dose, then wait and only take one dose at that time. Never try to catch up by taking two doses at once. This could cause toxic side effects. If you think you’ve taken too much of the drug, act right away. Call your doctor or local poison control center, or go to the nearest emergency room. You may not be able to tell whether this drug is working or not. It’s important that you take your medicine every day as directed by your doctor. Your doctor will monitor your condition and be able to tell if this drug is working. You may need to buy your own blood pressure monitoring machine to check your blood pressure at home. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. You may need to check your blood pressure at home using a blood pressure monitor. These are available for purchase at most pharmacies. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments. You may need to purchase a home blood pressure monitor to check your blood pressure at home. These are available at most pharmacies. Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other options that may work for you. NOTE: Healthline isn't a healthcare provider. We can't respond to health questions or give you medical advice. We’re unable to offer personal health advice, but we’ve partnered with trusted telehealth provider Amwell, who can connect you with a doctor. Try Amwell telehealth for id="post-9" class="post-9 page type-page status-publish has-post-thumbnail hentry">
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The website for the brother-sister writing duo, M.A. and J.L. Powers.
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